A NOVEL RNA-BINDING MOTIF IN INFLUENZA-A VIRUS NONSTRUCTURAL PROTEIN-1

The solution NMR structure of the RNA-binding domain from influenza vi rus non-structural protein 1 exhibits a novel dimeric six-helical prot ein fold, Distributions of basic residues and conserved salt bridges o f dimeric NS1(1-73) suggest that the face containing antiparallel heli ces 2 and 2' forms a novel arginine-rich nucleic acid binding motif.