C-TERMINAL DOMAIN OF TRANSCRIPTION COFACTOR PC4 REVEALS DIMERIC SSDNABINDING-SITE

Authors
BRANDSEN J WERTEN S VANDERVLIET PC MEISTERERNST M KROON J GROS P
Citation
J. Brandsen et al., C-TERMINAL DOMAIN OF TRANSCRIPTION COFACTOR PC4 REVEALS DIMERIC SSDNABINDING-SITE, Nature structural biology, 4(11), 1997, pp. 900-903
Citations number
29
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
11
Year of publication
1997
Pages
900 - 903
Database
ISI
SICI code
1072-8368(1997)4:11<900:CDOTCP>2.0.ZU;2-Y
Abstract
The crystal structure of human replication and transcription cofactor PC4(CTD) reveals a dimer with two single-stranded (ss)DNA binding chan nels running in opposite directions to each other. This arrangement su ggests a role in establishment or maintenance of melted DNA at promote rs or origins of replication.