THE DESIGN, SYNTHESIS AND TRANSMEMBRANE TRANSPORT STUDIES OF A BIOMIMETIC STEROL-BASED ION-CHANNEL

Authors
PECHULIS AD THOMPSON RJ FOJTIK JP SCHWARTZ HM LISEK CA FRYE LL
Citation
Ad. Pechulis et al., THE DESIGN, SYNTHESIS AND TRANSMEMBRANE TRANSPORT STUDIES OF A BIOMIMETIC STEROL-BASED ION-CHANNEL, Bioorganic & medicinal chemistry, 5(10), 1997, pp. 1893-1901
Citations number
43
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
5
Issue
10
Year of publication
1997
Pages
1893 - 1901
Database
ISI
SICI code
0968-0896(1997)5:10<1893:TDSATT>2.0.ZU;2-E
Abstract
A model sterol-based ion channel was rationally designed and synthesiz ed. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule la was incorp orated into phospholipid vesicles and shown to facilitate the transmem brane transport of sodium and lithium ions using alkali metal NMR spec troscopy. (C) 1997 Elsevier Science Ltd.