CARCINOSARCOMA OF THE UTERUS - A CLINICOPATHOLOGICAL MULTICENTER CTF STUDY

The purpose of this paper is to retrospectively analyze the clinical a nd pathological data of 118 cases of uterine carcinosarcoma. Prognosti c factors and management were evaluated. chi(2) and log-rank tests wer e performed. Surgical stage at time of surgery was the most important prognostic factor (P < 0.0001); in stage I-II disease depth of myometr ial invasion and lymphatic/vascular space involvement were significant ly related to outcome, whereas other factors were not useful. In stage I-II patients postoperative radiation did not improve 5-year disease- free survival. Survival curves in patients with advanced disease treat ed with cisplatin-containing regimens or with doxorubicin (without cis platin)-containing regimens were overlapping. (C) 1997 Academic Press.