A general methodology has been evaluated for the preparation of polyst
yrene-divinylbenzene resins which contain chiral groups derived from s
imple aminoacids. This approach requires the initial anchoring of an a
minoacid methyl ester followed by the modification of the resulting po
lymers using solid-phase techniques. The appropriate transformations o
f the supported chiral groups can be accomplished very efficiently. Re
sults obtained are much better than those described for similar reacti
ons carried out in solution.