ENDOGENOUS HEPOXILIN A(3), PRODUCED UNDER SHORT-DURATION OF HIGH SHEAR-STRESS, INHIBITS THROMBIN-INDUCED AGGREGATION IN HUMAN PLATELETS

Authors
MARGALIT A GRANOT Y
Citation
A. Margalit et Y. Granot, ENDOGENOUS HEPOXILIN A(3), PRODUCED UNDER SHORT-DURATION OF HIGH SHEAR-STRESS, INHIBITS THROMBIN-INDUCED AGGREGATION IN HUMAN PLATELETS, Biochimica et biophysica acta. Biomembranes, 1190(1), 1994, pp. 173-176
Citations number
18
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1190
Issue
1
Year of publication
1994
Pages
173 - 176
Database
ISI
SICI code
0005-2736(1994)1190:1<173:EHAPUS>2.0.ZU;2-M
Abstract
The effect of short duration of shear-stress (350 dyne/cm(2), 20 ms) o n platelet-aggregation has been assessed. This treatment inhibits thro mbin-induced but not ADP- or collagen-induced aggregation. The inhibit ory effect is mediated by endogenous hepoxilin A(3). This conclusion i s based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A(3) mimics the sh ear-stress effect.