THE IN-SITU SIZE OF THE DOPAMINE TRANSPORTER IS A TETRAMER AS ESTIMATED BY RADIATION INACTIVATION

Authors
MILNER HE BELIVEAU R JARVIS SM
Citation
He. Milner et al., THE IN-SITU SIZE OF THE DOPAMINE TRANSPORTER IS A TETRAMER AS ESTIMATED BY RADIATION INACTIVATION, Biochimica et biophysica acta. Biomembranes, 1190(1), 1994, pp. 185-187
Citations number
17
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1190
Issue
1
Year of publication
1994
Pages
185 - 187
Database
ISI
SICI code
0005-2736(1994)1190:1<185:TISOTD>2.0.ZU;2-U
Abstract
Radiation inactivation analysis of the mazindol-sensitive binding of t he dopamine transporter inhibitor, [H-3]GBR-12935 to canine striatal m embranes yielded a radiation inactivation target size of 278 +/- 16 kD a. This result, in conjunction with other findings in the literature d emonstrating that the molecular mass of the dopamine transporter is si milar to 70 kDa, suggests that the native form of the dopamine carrier in the neuronal membranes is a tetrameric assembly of identical 70 kD a subunits.