A PROTEIN PARTICLE VACCINE CONTAINING MULTIPLE MALARIA EPITOPES

Authors
GILBERT SC PLEBANSKI M HARRIS SJ ALLSOPP CEM THOMAS R LAYTON GT HILL AVS
Citation
Sc. Gilbert et al., A PROTEIN PARTICLE VACCINE CONTAINING MULTIPLE MALARIA EPITOPES, Nature biotechnology, 15(11), 1997, pp. 1280-1284
Citations number
28
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Nature biotechnology → ACNP
ISSN journal
10870156
Volume
15
Issue
11
Year of publication
1997
Pages
1280 - 1284
Database
ISI
SICI code
1087-0156(1997)15:11<1280:APPVCM>2.0.ZU;2-1
Abstract
Ty virus-like particles consist of a single protein species that can b e produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administrat ion without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flankin g sequences.