The molecular structures of three substituted 3-amino-2-benzoylaminopr
openoic acid derivatives, methyl (Z)-2-benzoylamino-3-dimethylaminopro
penoate (A), methyl mino-3-(4,6-dimethyl-2-pyrimidinylamino)propenoate
(B) and 6-dimethyl-2-pyrimidinylamino)propenoyl]-L-proline monohydrat
e (C), show that the configuration around the exocyclic C=C double bon
d is Z. The mechanisms of syntheses of (B) and (C) from (A) are confir
med as the Z configuration is preserved in the title compounds. The cr
ystal structure of compound (C) is stabilized via hydrogen bonds from
the solvent water molecules to the N atom bonded to the C=C double bon
d and to the two carbonyl 0 atoms in the molecule, each of the water m
olecules contributing to three hydrogen bonds. The bond lengths and an
gles agree with expected values.