Ov. Kazanskaya et al., ANF - A NOVEL CLASS OF VERTEBRATE HOMEOBOX GENES EXPRESSED AT THE ANTERIOR END OF THE MAIN EMBRYONIC AXIS, Gene, 200(1-2), 1997, pp. 25-34
Five novel genes homologous to the homeobox-containing genes Xanf-1 an
d Xanf-2 of Xenopus and Hesx-1/Rpx of mouse have been identified as a
result of a PCR survey of cDNA in sturgeon, zebrafish, newt, chicken a
nd human. Comparative analysis of the homeodomain primary structure of
these genes revealed that they belong to a novel class of homeobox ge
nes, which we name Anf. All genes of this class investigated so far ha
ve similar patterns of expression during early embryogenesis, characte
rized by maximal transcript levels being present at the anterior extre
mity of the main embryonic body axis. The data obtained also suggest t
hat, despite considerable high structural divergence between their hom
eodomains, all known Anf genes may be orthologues, and thus represent
one of the most quickly evolving classes of vertebrate homeobox genes.
(C) 1997 Elsevier Science B.V.