IN-VITRO ACTIVITY OF CEFPODOXIME AND PRIS TINAMYCINE ON ISOLATES OF HAEMOPHILUS-INFLUENZAE AND STREPTOCOCCUS-PNEUMONIAE DURING ACUTE SINUSITIS IN ADULTS

Minimal inhibitory concentrations (MIG) of cefpodoxime and pristinamyc in were determined on 45 isolates of Streptococcus pneumoniae and 56 i solates of Haemophilus influenzae collected during acute sinusitis in adults. The MIC50 of cefpodaxime and pristinamycin against H. influenz ae were estimated at 0.06 mg/l and 0.5 mg/l, respectively, regardless the production of beta-lactamase. The MIC50 of cefpodoxime against pen icillin-susceptible isolates of S. pneumoniae were estimated at 0.03 m gil, and at l mg/l for the penicillin-intermediate and resistant isola tes of S. pneumoniae. The MIC50 of pristinamycin against penicillin-su sceptible and resistant isolates of S. pneumoniae were estimated at 0. 25 mg/l. These results show that in vitro activity of these two antibi otics is adapted to the main pathogens responsible for acute sinusitis .