THE SHORT-TERM EFFECTS OF CISPLATIN CHEMOTHERAPY ON BONE TURNOVER

Cisplatin is an effective agent in the treatment of osteosarcoma of bo ne but little is known of its effects on normal bone turnover, Twenty- four dogs divided into three study groups were used to study the effec t of cisplatin on normal bone turnover at the distant site of surgery, Group 1 served as the control group, group 2 received four cycles of cisplatin every 3 weeks before the surgery, and group 3 received four cycles postoperatively, The bone turnover rate was evaluated by measur ing levels of systemic bone markers, osteocalcin, alkaline phospohatas e, urine pyridinoline cross-links, and by determination histomorphomet ric indices, Histomorphological analysis showed poor correlation on bo ne formation with systemic bone markers at distant sites of surgery, H istomorphometrically normal bone turnover was affected by administrati on of cisplatin, but the effect was temporary, late, and less signific ant than what occurred at the surgical site, Our data showed that sign ificant effects of cisplatin are observed at the site of active cellul ar induction and proliferation, such as implant-host interface, and le ss effects are seen at the sites of normal bone turnover.