S. Bhattacharya et al., THIENO[3',2'-4,5][1]BENZOTHIENO[2,3-D]PYRIMIDINE DERIVATIVES - SYNTHESIS AND CONFORMATION, Journal of the Chemical Society. Perkin transactions. I, (6), 1994, pp. 689-693
An efficient route is reported for the synthesis of derivatives of the
thieno[3',2':4,5][l]benzothieno[2,3-d]pyrimidine system 6 with a subs
tituent (oxygen atom or amino group) in the bay region. These molecule
s are shown by extensive MM calculations to show a significant degree
of helical distortion.