SYNTHESIS OF ALOPHENYL)-5-(PYRIDYL)-3H-1,2,4-TRIAZOLE-3-THIONES

Authors
IQBAL R RAMA NH YUNUS U SAEED A ZAMANI K
Citation
R. Iqbal et al., SYNTHESIS OF ALOPHENYL)-5-(PYRIDYL)-3H-1,2,4-TRIAZOLE-3-THIONES, Journal of the Chemical Society of Pakistan, 19(2), 1997, pp. 145-149
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society of Pakistan → ACNP
ISSN journal
02535106
Volume
19
Issue
2
Year of publication
1997
Pages
145 - 149
Database
ISI
SICI code
0253-5106(1997)19:2<145:SOA>2.0.ZU;2-Y
Abstract
Nine alophenyl)-5-(pyridyl)-3H-1,2,4-triazole-3-thiones (15-23) were s ynthesized by the reaction of 4-halophenyl isothiocyanates (4a-c) and pyridinecarboxylic acid hydrazides (5a-c) through 1,4-disubstituted th iosemicarbizide intermediates (6-14). Base-catalysed intramolecular de hydrative cyclization of these intermediates furnished the thiones (15 -23) in good yields (50-78%). The products were characterized on the b asis of their elemental analysis, IR and mass spectral data.