BIOLOGICAL HALF-LIFE OF BROMINE IN THE RAT-THYROID

Authors
VOBECKY M BABICKY A LENER J PAVELKA S
Citation
M. Vobecky et al., BIOLOGICAL HALF-LIFE OF BROMINE IN THE RAT-THYROID, Physiologia bohemoslovaca, 46(5), 1997, pp. 385-389
Citations number
9
Journal title
Physiologia bohemoslovaca → ACNP
ISSN journal
03699463
Volume
46
Issue
5
Year of publication
1997
Pages
385 - 389
Database
ISI
SICI code
0369-9463(1997)46:5<385:BHOBIT>2.0.ZU;2-4
Abstract
The biological half-life of bromine in the rat thyroid was determined by measuring the radioactivity of thyroids of animals which continuous ly received B-82, labelled bromide in their food. The value of this ha lf-life (110 h) is practically the same as the biological half-life of iodine. The rate of establishing the I/Br concentration ratio in the thyroid depends on the biological half-life of bromine. The mechanism of this process depends on the state of iodine supply. When the supply is sufficient, the iodine concentration ire the thyroid remains const ant, while during iodine deficiency the iodine atoms are replaced by a toms of bromine.