STIMULATION BY CLOMIFEN IN INTRACYTOPLASM IC SPERM INJECTION (ICSI)

Stimulation by Clomifen in Intracysmoplastic Sperm Injection (ICSI): T his prospective trial was planned to determine the value of a soft sti mulation protocol using 100 mg clomifen citrate from cycle day 3 to 7 in natural cycles as a preparation for an intracytoplasmic sperm injec tion (ICSI). 17 endocrinologically normal patients were stimulated who were suffering from a male factor subfertility. 13 patients showed a good response and a oocyte pickup was performed in these cases. 22 ooc ytes were retrieved in 10 patients, most of these oocytes were in meta phase 11 (91%), the fertilisation rate was 82% (n=18). 11 transfers we re performed, 2 clinical pregnancies could be achieved, one ended in a n early abortion, one pregnancy was ongoing. To conclude: we can show that stimulation for ICSI using low-dose CC is feasible. The transfer rate was 100% per successful pick-up (10 patients). The protocol is ea sy to perform, cheap and the risk of ovarian hyperstimulation syndrome and multiple pregnancies is minimal. Patients accept this form of sti mulation as very comfortable. These advantages are discussed.