HEPATIC LIPASE GENE POLYMORPHISMS INFLUENCE PLASMA HDL LEVELS - RESULTS FROM FINNISH EARS PARTICIPANTS

Hepatic lipase (HL), a triglyceride lipase found in liver, adrenals, t estes, and ovaries, takes part in the uptake, remodeling, and function of lipoproteins including HDL, as well as VLDL and chylomicrons. In t he present study, the genotype distribution of five HL polymorphisms ( -C480T, V133V, T202T, L334F, T457T) and their association to plasma li pid values were investigated. The study participants included 92 stude nts with paternal history of myocardial infarction before the age of 5 5 and 194 matched control subjects, ie, the Finnish participants of th e European Atherosclerosis Research Study (EARS). The allele T of the HL polymorphism -C480T showed an association with elevated HDL, apoA-I , and LpA-I values (ANOVA P<.01). No difference in genotype distributi on was observed in the offspring with and without paternal history of myocardial infarction.