DIAGNOSIS OF CEREBROSPINAL-FLUID RHINORRH EA

Cerebrospinal fluid (CSF) rhinorrhea presents not only a therapeutic c hallenge, but a diagnostic challenge as well. This is especially true in the case of atraumatic spontaneous leakage, which is often only min imal in quantity and can occur intermittently. The purpose of this pap er is to compare the current methods of evaluation of CSF Rhinorrhea ( beta(2)-Transferrin assay, high resolution computed tomography [HRCT], and computotomographic cisternography [CTC]) and develop a diagnostic protocol. Method: A retrospective analysis was performed of 61 patien ts who underwent operation for CSF rhinorrhea between 1988 and 1996 co mparing the method of preoperative diagnosis and intraoperative findin gs. Results: beta(2)-transferrin-determination in the nasal discharge had a sensitivity of 79% (33/42), HRCT correctly identified the defect in 84% (48/57) of cases, and CTC correctly localized the pathology in 72% (18/25) of the patients. Conclusion: The sensitivity of each CSF rhinorrhea diagnosis method is less than 90%. It is our opinion that w ith the current level of technology a combined approach is optimal wit h two or more of the above studies. A diagnosis scheme is presented to manage step by step this challenging and potentially lethal problem.