STUDIES ON FUSED PYRIMIDINE-DERIVATIVES .12. REACTION OF -5-FORMYL-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONES WITH ALPHA-AMINO-ACID DERIVATIVES

Citation
T. Inazumi et al., STUDIES ON FUSED PYRIMIDINE-DERIVATIVES .12. REACTION OF -5-FORMYL-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONES WITH ALPHA-AMINO-ACID DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (5), 1994, pp. 557-564
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
ISSN journal
0300922X
Issue
5
Year of publication
1994
Pages
557 - 564
Database
ISI
SICI code
0300-922X(1994):5<557:SOFP.R>2.0.ZU;2-7
Abstract
The reactions of 2-enylamino)-5-formyl-1,3-dimethylpyrimidine-2.4(1 H, 3H)-diones 1 with alpha-amino acid derivatives are described. The reac tion of compounds of 1 with N-substituted amino acid derivatives affor ds azomethine ylides through well known condensation processes. A simi lar reaction with N-unsubstituted amino acid derivatives gives pyrimid o [4,5-b]azepine derivatives via an intramolecular ene reaction of the imines. obtained from diones 1 and N-unsubstituted amino acid derivat ives. The reaction profiles depend upon the N-substituent patterns of the amino acid derivatives utilised.