COLLAGEN GENE-EXPRESSION IN THE NEOMATRIX OF CARCINOMA OF THE BREAST

Citation
Il. Wapnir et al., COLLAGEN GENE-EXPRESSION IN THE NEOMATRIX OF CARCINOMA OF THE BREAST, Invasion & metastasis, 16(6), 1997, pp. 308-316
Citations number
35
Categorie Soggetti
Oncology
Journal title
ISSN journal
02511789
Volume
16
Issue
6
Year of publication
1997
Pages
308 - 316
Database
ISI
SICI code
0251-1789(1997)16:6<308:CGITNO>2.0.ZU;2-Y
Abstract
Excessive deposition of extracellular matrix or neomatrix is a charact eristic of desmoplastic invasive breast carcinomas. Type I and III col lagens are abundant neomatrix components. Archival breast tissue secti ons were studied using S-35-labeled cDNA probes for alpha 1(I) and alp ha 1(III) procollagen and in situ hybridization. Among the 33 invasive breast cancers, hybridization was seen forming a gradient-like patter n in fibroblasts closest to tumor cells. In the 10 ductal carcinomas i n situ studied, a ring-like pattern of hybridization was seen in proxi mity to the basement membrane zone. Adjacent normal and benign tissues did not demonstrate the patterns of hybridization described in malign ant tissues. Gene expression for neomatrix interstitial collagens occu rs before there is evidence of invasion in carcinoma of the breast.