EFFECTS OF EICOSAPENTAENOIC ACID (EPA) ON PROSTACYCLIN PRODUCTION IN DIABETICS - GC MS ANALYSIS OF PGI(2) AND PGI(3) LEVELS/

Authors
NISHIKAWA M HISHINUMA T NAGATA K KOSEKI Y SUZUKI K MIZUGAKI M
Citation
M. Nishikawa et al., EFFECTS OF EICOSAPENTAENOIC ACID (EPA) ON PROSTACYCLIN PRODUCTION IN DIABETICS - GC MS ANALYSIS OF PGI(2) AND PGI(3) LEVELS/, Methods and findings in experimental and clinical pharmacology, 19(6), 1997, pp. 429-433
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
19
Issue
6
Year of publication
1997
Pages
429 - 433
Database
ISI
SICI code
0379-0355(1997)19:6<429:EOEA(O>2.0.ZU;2-#
Abstract
The enzymatic metabolites, 6-keto-PGF(1 alpha) and Delta(17)-6-keto-PG F(1 alpha), were measured by gas chromatography/high resolution-select ed ion monitoring (GC/HR-SIM) as markers of prostaglandin I-2 (PGI(2)) and prostacyclin (PGI(3)) production in human sera. Eicosapentaenoic acid (EPA) ethyl ester (1.8 g/day) was administered to 12 noninsulin-d ependent diabetes mellitus(NIDDM) patients for 2 weeks. Forty patients with similar NIDDM were followed as a control group. PGI(3) productio n in sera was significantly increased in the EPA intake group in compa rison with the control group. These findings suggest that EPA intake p revents complications of diabetes mellitus, such as microangiopathy an d vaso-occlusive diseases.