M. Nishikawa et al., EFFECTS OF EICOSAPENTAENOIC ACID (EPA) ON PROSTACYCLIN PRODUCTION IN DIABETICS - GC MS ANALYSIS OF PGI(2) AND PGI(3) LEVELS/, Methods and findings in experimental and clinical pharmacology, 19(6), 1997, pp. 429-433
The enzymatic metabolites, 6-keto-PGF(1 alpha) and Delta(17)-6-keto-PG
F(1 alpha), were measured by gas chromatography/high resolution-select
ed ion monitoring (GC/HR-SIM) as markers of prostaglandin I-2 (PGI(2))
and prostacyclin (PGI(3)) production in human sera. Eicosapentaenoic
acid (EPA) ethyl ester (1.8 g/day) was administered to 12 noninsulin-d
ependent diabetes mellitus(NIDDM) patients for 2 weeks. Forty patients
with similar NIDDM were followed as a control group. PGI(3) productio
n in sera was significantly increased in the EPA intake group in compa
rison with the control group. These findings suggest that EPA intake p
revents complications of diabetes mellitus, such as microangiopathy an
d vaso-occlusive diseases.