EXTENDED-INTERVAL DOSING OF AMINOGLYCOSIDES

Aminoglycosides are efficacious agents. Their use has declined partly because of the development of newer, presumably less toxic agents. Res earch shows that aminoglycosides can be dosed differently than in the past, maintaining efficacy while reducing aminoglycoside toxicities. A minoglycosides administered with newer agents mag help overcome antibi otic bacterial resistance and thus yield safe and more effective thera py. This study Focused on the efficacy and safety of the aminoglycosid es extended-interval dosing regimen and was conducted by a search of t he literature. Data fi om The Mount Sinai Hospital regarding bacterial resistance patterns we-re collected. A nomogram describing the admini stration of the extended-interval dosing regimen is provided. Extended -interval dosing of aminoglycosides is as efficacious as administering these agents every 8 hours and may result in lower rates of toxicitie s, Extended-interval dosing also may cast less and be easier to admini ster. Aminoglycosides are less susceptible to bacterial resistance tha n many of the newer, currently favored antibiotics, Increasing the usa ge of aminoglycosides is likely to be safe and beneficial in the treat ment of certain bacterial infections.