HUMAN UMBILICAL-CORD BLOOD MYELOID PROGENITOR CELLS ARE RELATIVELY CHEMORESISTANT - A POTENTIAL MODEL FOR AUTOLOGOUS TRANSPLANTATIONS IN HIV-INFECTED NEWBORNS
A. Toren et al., HUMAN UMBILICAL-CORD BLOOD MYELOID PROGENITOR CELLS ARE RELATIVELY CHEMORESISTANT - A POTENTIAL MODEL FOR AUTOLOGOUS TRANSPLANTATIONS IN HIV-INFECTED NEWBORNS, American journal of hematology, 56(3), 1997, pp. 161-167
Vertical transmission from mother to child occurs in 15-39% of women i
nfected with the human immunodeficiency Virus (HIV), Stem cell transpl
antation has recently been suggested as a potential therapy for patien
ts with HIV infection, We have examined the possible advantages of hum
an cord blood (HUCB) stem cells over bone marrow (BM) stem cells in th
e treatment of HIV-infected newborns, HUCB myeloid progenitors were fo
und to be statistically more resistant to interferon-alpha (IFN-alpha)
, cytarabine (ARA-C), and eilatin than BM myeloid progenitor cells gro
wn with IL-3 (P< 0.05), HUCB treated with IFN-alpha, ARA-C, and eilati
n demonstrated a significantly higher capacity for self-renewal manife
sted by delta assay following 7 days in liquid culture, We, therefore,
suggest that HUCB purged by anti-HIV drugs may be a source for autolo
gous transplantation in HIV-infected newborns. (C) 1997 Wiley-Liss, In
c.