M. Schirmer et al., THE SAFETY PROFILE OF LOW-DOSE CLADRIBINE IN REFRACTORY RHEUMATOID-ARTHRITIS - A PILOT TRIAL, Scandinavian journal of rheumatology, 26(5), 1997, pp. 376-379
Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog wi
th specific toxicity to lymphocytes. As lymphocytes play a major role
in rheumatoid arthritis (RA), we assessed the safety profile of low-do
se 2-CdA in patients who were refractory to more than three disease-mo
difying drugs. Five patients were given a subcutaneous dosage of 0.05
mg/kg 2-CdA weekly over a period of 8 weeks. Of the lymphocyte subsets
, both T and B cells decreased below the normal range, whereas natural
killer cells remained stable. These changes were the only side-effect
s noted during treatment and 4 weeks afterwards. In one patient a pace
maker was implanted for reasons unlikely to be related to 2-CdA admini
stration. We conclude that even low-dose 2-CdA (0.05 mg/kg) can decrea
se T and B cell populations in patients with refractor RA, but other s
ide-effects are unlikely. For assessing the possible clinical efficacy
of low-dose 2-CdA further studies are warranted.