SERUM IGA1 AND IGA2 SUBCLASS ANTIBODIES AGAINST COLLAGENS IN PATIENTSWITH ANKYLOSING-SPONDYLITIS

Authors
TANI Y SATO H TANAKA N MORI K DOIDA Y HUKUDA S
Citation
Y. Tani et al., SERUM IGA1 AND IGA2 SUBCLASS ANTIBODIES AGAINST COLLAGENS IN PATIENTSWITH ANKYLOSING-SPONDYLITIS, Scandinavian journal of rheumatology, 26(5), 1997, pp. 380-382
Citations number
10
Categorie Soggetti
Rheumatology
Journal title
Scandinavian journal of rheumatology → ACNP
ISSN journal
03009742
Volume
26
Issue
5
Year of publication
1997
Pages
380 - 382
Database
ISI
SICI code
0300-9742(1997)26:5<380:SIAISA>2.0.ZU;2-Z
Abstract
We measured IgA1 and IgA2 subclass antibody levels against human type I, II, III and IV collagens in patients with ankylosing spondylitis (A S) by enzyme linked immunosorbent assay (ELISA). Significant elevation s of IgA1 antibodies against type II collagen (p<0.01) and IgA2 antibo dies against type I (p<0.001), III (p<0.001), and IV (p<0.01) collagen s were observed in AS patients compared with those of healthy controls . These findings suggest that serum IgA antibodies against type I, III and IV collagens were mainly produced in secretory lesions in AS pati ents.