HYDROLYSIS OF NITRITE ESTERS - PUTATIVE INTERMEDIATES IN THE BIOTRANSFORMATION OF ORGANIC NITRATES

Authors
BUCKELL F HARTRY JD RAJALINGAM U BENNETT BM WHITNEY RA THATCHER GRJ
Citation
F. Buckell et al., HYDROLYSIS OF NITRITE ESTERS - PUTATIVE INTERMEDIATES IN THE BIOTRANSFORMATION OF ORGANIC NITRATES, Perkin transactions. 2, (3), 1994, pp. 401-403
Citations number
18
Categorie Soggetti
Chemistry Physical","Chemistry Inorganic & Nuclear
Journal title
Perkin transactions. 2 → ACNP
ISSN journal
03009580
Issue
3
Year of publication
1994
Pages
401 - 403
Database
ISI
SICI code
0300-9580(1994):3<401:HONE-P>2.0.ZU;2-B
Abstract
Study and comparison of the pH-independent hydrolysis of eight alkyl n itrites shows 3-nitroso-1,2-glyceryl dinitrate, a putative intermediat e in the biotransformation of glyceryl trinitrate, to be unexpectedly reactive and too labile to be detected as a biotransformation intermed iate in aqueous solution, suggesting a role for neighbouring group par ticipation by the beta-nitrate group.