THE PREPARATION OF I-125 LABELED SODIUM POLYSTYRENE SULFONATE

Authors
HARRISON I HIGGO JJW
Citation
I. Harrison et Jjw. Higgo, THE PREPARATION OF I-125 LABELED SODIUM POLYSTYRENE SULFONATE, Applied radiation and isotopes, 45(3), 1994, pp. 345-351
Citations number
8
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
45
Issue
3
Year of publication
1994
Pages
345 - 351
Database
ISI
SICI code
0969-8043(1994)45:3<345:TPOILS>2.0.ZU;2-Y
Abstract
The anionic polymer, sodium polystyrene p-sulphonate (PSSNa), was labe lled with iodine-125. Standard radio-iodination for proteins proceeds via phenol groups. As PSSNa contains no phenolic functions these were introduced by reaction with sodium hydroxide. The optimized conditions gave barely discernible phenolic incorporation so the properties of t he bulk PSSNa were not noticeably altered. The modified PSSNa was then radio-iodinated by the standard technique. The yield, activity and st ability of the product were determined by size exclusion chromatograph y.