SPINAL COADMINISTRATION OF PEPTIDE SUBSTANCE-P ANTAGONIST INCREASES ANTINOCICEPTIVE EFFECT OF THE OPIOID PEPTIDE BIPHALIN

Authors
MISTEREK K MASZCZYNSKA I DOROCIAK A GUMULKA SW CARR DB SZYFELBEIN SK LIPKOWSKI AW
Citation
K. Misterek et al., SPINAL COADMINISTRATION OF PEPTIDE SUBSTANCE-P ANTAGONIST INCREASES ANTINOCICEPTIVE EFFECT OF THE OPIOID PEPTIDE BIPHALIN, Life sciences, 54(14), 1994, pp. 939-944
Citations number
27
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
14
Year of publication
1994
Pages
939 - 944
Database
ISI
SICI code
0024-3205(1994)54:14<939:SCOPSA>2.0.ZU;2-C
Abstract
Intrathecal injection of 0.25 mu g of undecapeptide substance P antago nist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal in jection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Coadministration of SPA (at subt oxic doses) increased BIP's antinociceptive effect. Naltrexone reverse d analgesia due to BIP alone as well as after BIP+SPA.