SYMMETRY AND KINETIC OPTIMIZATION OF PROTEINLIKE HETEROPOLYMERS

Authors
NELSON ED TENEYCK F ONUCHIC JN
Citation
Ed. Nelson et al., SYMMETRY AND KINETIC OPTIMIZATION OF PROTEINLIKE HETEROPOLYMERS, Physical review letters, 79(18), 1997, pp. 3534-3537
Citations number
30
Categorie Soggetti
Physics
Journal title
Physical review letters → ACNP
ISSN journal
00319007
Volume
79
Issue
18
Year of publication
1997
Pages
3534 - 3537
Database
ISI
SICI code
0031-9007(1997)79:18<3534:SAKOOP>2.0.ZU;2-4
Abstract
The relationship between optimization, evolutionary sequence selection , and structural symmetry is investigated for an elementary continuum model of proteins in which a complete correspondence between sequence and structure can be established. It is found that (i) kinetic optimiz ation (minimal frustration) is strongly connected with ground state sy mmetry and (ii) the highest symmetry ground state is the least fragile to sequence mutations.