So. Skarli et al., MELANOMA ARISING IN A CERVICAL SPINAL NERVE ROOT - REPORT OF A CASE WITH A BENIGN COURSE AND MALIGNANT FEATURES, Neurosurgery, 34(3), 1994, pp. 533-537
A 20-YEAR-OLD CAUCASIAN woman with a 5-year history of right arm, neck
, and back pain sought treatment when an automobile accident (4 months
before admission) exacerbated her pain. Magnetic resonance imaging re
vealed an intra- and extradural mass compressing the spinal cord at th
e C5-C6 level. It also extended into and widened the neural foramen, m
imicking a neurofibroma. A single cafe-au-lait spot was discovered in
the inguinal region. A two-staged surgical resection was performed on
an apparent hemorrhagic C6 nerve root mass. The mass exhibited diagnos
tic features of a malignant melanoma histologically, immunocytochemica
lly, and ultrastructurally. A search for a primary lesion outside the
nervous system or other metastases during an 8-year period from the on
set of symptoms has been negative. The patient's chronic history, evid
ence of neural foraminal enlargement, and the absence of other maligna
nt melanoma lesions or subsequent metastases indicates that this lesio
n may be a primary melanoma of the nerve root with a benign course.