Purpose: We studied 17 patients with periventricular nodular heterotop
ia (PNH) to further investigate the electroclinical pictures and semio
logy of the associated seizures. Methods: PNH was diagnosed by means o
f magnetic resonance imaging (MRI). The patients' clinical and familia
l histories were carefully analyzed, and their electroclinical feature
s and course of epilepsy followed for periods ranging from 10 months t
o 22 years. The electroclinical data were compared with those of previ
ously reported PNH cases. Results: The patients were subdivided into t
hose with bilateral (7) and unilateral (10) PNH. The former were mainl
y characterized by structural abnormalities in the posterior cerebral
fossa and multiple seizure types; the latter were characterized by the
paratrigonal location of the malformation and, frequently, by element
ary seizures with a visual or auditory onset. Focal seizures were drug
resistant in most cases. The interictal EEG abnormalities were always
focal and consistent with the location of the PNH. A previously unrep
orted photic driving of posterior background activity was observed in
all patients and was always consistent with the PNH location. Conclusi
ons: Our present findings and previously reported data show that bilat
eral and unilateral PNH cases are different in their morphological and
electroclinical features and may be determined by different etiologie
s. The female predominance, frequent familial occurrence, and positive
family history for epilepsy suggest that genetic factors may be invol
ved in the genesis of bilateral and symmetrical PNH, whereas the prese
nce of prenatal risk factors and its location in the watershed paratri
gonal area suggest that vascular mechanisms may determine unilateral P
NH.