Jf. Cormier et Jb. Plomley, NORMAL-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC RESOLUTION OF 5'-O-PROTECTED DEOXYNUCLEOSIDE METHYLPHOSPHONAMIDITES, Journal of chromatography, 662(2), 1994, pp. 401-406
High-performance liquid chromatography has been used for the analytica
l and preparative resolution of some nucleoside methylphosphonamidites
. The pure diastereomers were required for a study on the mechanism of
the coupling reactions of these compounds.