MONITORING THE CONVERSION OF CYCLOHEPTANONE TO METHYL 7-OXOHEPTANOATEBY GAS-CHROMATOGRAPHY

Authors
WAKHARKAR RD BISWAS SS BORATE HB PONDE DE
Citation
Rd. Wakharkar et al., MONITORING THE CONVERSION OF CYCLOHEPTANONE TO METHYL 7-OXOHEPTANOATEBY GAS-CHROMATOGRAPHY, Journal of chromatography, 662(2), 1994, pp. 420-423
Citations number
6
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography → ACNP
Volume
662
Issue
2
Year of publication
1994
Pages
420 - 423
Database
ISI
SICI code
Abstract
Methyl 7-oxoheptanoate is an important intermediate required for the s ynthesis of prostaglandins by three-component coupling methodology. It can be efficiently prepared in two steps from cycloheptanone via the formation of 1-methoxy-1-cycloheptene and its ozonolysis. An efficient and reproducible method for the baseline separation of the components in the reaction mixtures in the above steps by gas chromatography is reported.