Rd. Wakharkar et al., MONITORING THE CONVERSION OF CYCLOHEPTANONE TO METHYL 7-OXOHEPTANOATEBY GAS-CHROMATOGRAPHY, Journal of chromatography, 662(2), 1994, pp. 420-423
Methyl 7-oxoheptanoate is an important intermediate required for the s
ynthesis of prostaglandins by three-component coupling methodology. It
can be efficiently prepared in two steps from cycloheptanone via the
formation of 1-methoxy-1-cycloheptene and its ozonolysis. An efficient
and reproducible method for the baseline separation of the components
in the reaction mixtures in the above steps by gas chromatography is
reported.