Background Previous studies show that criticism by relatives during ac
ute depressive illness predicts relapse over nine months, but the cour
se of criticism over time and its relation to the course of illness, h
ave not been examined in depressed patients. Method Thirty-nine depres
sed patients and their partners, were interviewed separately at three-
monthly intervals over about one year. illness was assessed by Researc
h Diagnostic Criteria and Hamilton Depression Rating Scale. Criticism
was measured by the Camberwell Family Interview. Results Criticism whe
n patients were most depressed predicted neither remission nor subsequ
ent relapse. Patients who fully recovered, with or without later relap
se, had partners who were consistently uncritical, or critical only at
presentation. Patients with residual symptoms during remission had mo
re persistently critical partners. Conclusions The nature of the assoc
iation between criticism and depression could not be unequivocally est
ablished, although it appeared likely that continuing criticism was a
result of continuing depression. Relatives' understanding of the illne
ss may mediate between levels of criticism and the course of depressio
n.