COMPARATIVE IN-VITRO EVALUATION OF PIPERACILLIN TAZOBACTAM IN A TERTIARY CARE HOSPITAL/

Citation
E. Plastsouka et al., COMPARATIVE IN-VITRO EVALUATION OF PIPERACILLIN TAZOBACTAM IN A TERTIARY CARE HOSPITAL/, Journal of chemotherapy, 9(5), 1997, pp. 336-340
Citations number
17
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
ISSN journal
1120009X
Volume
9
Issue
5
Year of publication
1997
Pages
336 - 340
Database
ISI
SICI code
1120-009X(1997)9:5<336:CIEOPT>2.0.ZU;2-E
Abstract
Bacterial resistance is usually a serious problem in tertiary care hos pitals. The aim of this in vitro study mas to evaluate the beta-lactam ase inhibitor combination piperacillin/tazobactam in a hospital enviro nment with high bacterial resistance rates and compare it with other b eta-lactam agents. Three hundred and sixty-two isolates from various c linical materials were studied during the period March-August 1996. Ma terial for culture was collected from patients of all the wards of our hospital, with the majority being from the Intensive Care Unit (45%). Pathogenic Gram-positive and Gram-negative bacteria with high resista nce rates and beta-lactamase production were studied (staphylococci, e nterococci, Enterobacteriaceae, Pseudomonas). Significant bacterial re sistance rates were identified for ceftazidime (50% for Klebsiellae, 6 0% for Enterobacter spp, 60% for Proteus spp, 33% for Pseudomonas spp, 75% for Acinetobacter spp) and ciprofloxacin (33% for both Klebsiella e and Enterobacter spp, 67% for Pseudomonas spp, 50% Acinetobacter spp ). Fifty percent of Enterococcus isolates were resistant co ciprofloxa cin but all of them were susceptible to piperacillin/tazobactam, amoxi cillin/clavulanate and imipenem. The antibacterial activity of piperac illin/tazobactam (susceptibility rates 83 to 100% for Enterobacteriace ae, 83% for Pseudomonas spp and 75% for Acinetobacter spp) was higher than that of ceftazidime, piperacillin and ciprofloxacin. Imipenem, be ing mostly a reserve product, showed higher activity against Acinetoba cter, Klebsiella and Enterobacter species.