It has been known since the 1940s that nail polishes contain allergeni
c ingredients. The aim of this study was to clarify whether the nail p
olishes on the market today contain significant amounts of allergens,
and what the solvents are. The following ingredients were determined:
toluene, toluene sulfonamide formaldehyde resins, free formaldehyde, a
crylates, methacrylates and certain organic solvents. The study compri
sed 20 brands and 42 samples. All the nail polishes analysed contained
allergenic toluene sulfonamide formaldehyde resins (TSFR), in concent
rations from 0.08 to 11.0%. The concentration of total formaldehyde va
ried from 0.02% to 0.5%. The more TSFR a nail polish contained, the hi
gher was its formaldehyde content. Probably not only TSFR-allergic but
also formaldehyde-allergic persons may get dermatitis from many of th
e nail polishes studied. The concentrations of acrylates and methacryl
ates were so small that they are of practical significance only to tho
se previously sensitized to acrylates. Of the organic solvents, toluen
e was still widely used, whereas xylene was found in only 1 product. T
he nail polishes on the market today are not safe for all consumers. H
owever, according to the regulations of the European Union, the packag
ing labeling of all cosmetic products must be supplied with a list of
ingredients from the beginning of 1998. This will help the consumer to
avoid allergenic products. A better alternative could, however, be to
substitute the most allergenic ingredients with substances possessing
minor allergy potency. (C) Munksgaard, 1997.