THE MURINE P84 NEURAL ADHESION MOLECULE IS SHPS-1, A MEMBER OF THE PHOSPHATASE-BINDING PROTEIN FAMILY

P84 is a neuronal membrane glycoprotein that promotes the attachment a nd neurite outgrowth of cultured murine cerebellar cells. The heteroph ilic adhesive properties of P84 and its localization at sites of synap togenesis suggest that it may be involved in regulation of synapse for mation or maintenance. P84 is expressed in subsets of neurons througho ut the CNS. By cloning the cDNA encoding murine P84, we have discovere d that this molecule is a member of a family of phosphatase-binding pr oteins and is identical to the murine SHPS-1 cDNA. Here we report the cloning of two alternatively spliced forms of P84 and describe its loc alization within the CNS by in situ hybridization.