RHEUMATIC HEART-DISEASE AND SNEDDONS SYNDROME

Background As the pathogenesis of Sneddon's syndrome is unknown, resea rch for associated disease can facilitate our understanding. Case Desc ription of nine patients with Sneddon's syndrome, three had rheumatic heart disease (mitral valve stenosis, regurgitation, or both) due to r heumatic fever or Sydenham's chorea. Transient anticardiolipin antibod ies or positive skin lupus band test were present. Conclusions Sneddon 's syndrome can have multiple causes. In some patients, rheumatic hear t disease is a possible causal association.