STUDY OF THE THERAPEUTIC AND PROPHYLACTIC EFFECTS OF IMMUNOMODIFIERS IN EXPERIMENTAL INFECTIONS CAUSED BY MARBURG, EBOLA, AND VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUSES
An. Sergeyev et al., STUDY OF THE THERAPEUTIC AND PROPHYLACTIC EFFECTS OF IMMUNOMODIFIERS IN EXPERIMENTAL INFECTIONS CAUSED BY MARBURG, EBOLA, AND VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUSES, Voprosy virusologii, 42(5), 1997, pp. 226-229
Therapeutic and prophylactic effects of immunomodifiers ridostin, reaf
eron, and polyribonate used alone and in various combinations were ass
essed in experiments on guinea pigs infected with Venezuelan equine en
cephalomyelitis (VEE) (strain Trinidad), Marburg (strain Popp), and Eb
ola (M/C-8 variant of Zaire strain) viruses at doses 5 to 20 respirato
ry LD50 through the respiratory airways. Urgent prophylactic simultane
ous intramuscular and intranasal administration of ridostin protected
the animals infected with Marburg virus (p = 0.1) and prolonged their
life span by 2.4 days (p = 0.15). In Ebola infection a combination of
ridostin and reaferon appreciably prolonged the mean life span. by 2.9
days (p = 0.04). In VEE ridostin alone or in combination with reafero
ne appreciably increased the share of survivors; ridostin with reafero
n and polyribonate notably prolonged the mean life spall of infected a
nimals. None of these drugs or combinations produced an appreciable th
erapeutic effect in any of the studied infections.