IMPROVED ANTIMICROBIAL ACTIVITY OF DU-6859A, A NEW FLUOROQUINOLONE, AGAINST QUINOLONE-RESISTANT KLEBSIELLA-PNEUMONIAE AND ENTEROBACTER-CLOACAE ISOLATES WITH ALTERATIONS IN GYRA AND PARC PROTEINS

Authors
DEGUCHI T YASUDA M KAWAMURA T NAKANO M OZEKI S KANEMATSU E NISHINO Y KAWADA Y
Citation
T. Deguchi et al., IMPROVED ANTIMICROBIAL ACTIVITY OF DU-6859A, A NEW FLUOROQUINOLONE, AGAINST QUINOLONE-RESISTANT KLEBSIELLA-PNEUMONIAE AND ENTEROBACTER-CLOACAE ISOLATES WITH ALTERATIONS IN GYRA AND PARC PROTEINS, Antimicrobial agents and chemotherapy, 41(11), 1997, pp. 2544-2546
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
11
Year of publication
1997
Pages
2544 - 2546
Database
ISI
SICI code
0066-4804(1997)41:11<2544:IAAODA>2.0.ZU;2-#
Abstract
MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumonia e isolates and 21 Enterobacter cloacae isolates with altered GyrA or a ltered GyrA and ParC ranged from less than or equal to 0.025 to 6.25 m u g/ml and from 0.1 to 3.13 mu g/ml respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneu moniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater acti vity than currently available fluoroquinolones.