IN-VITRO ACTIVITIES OF AN INVESTIGATIONAL QUINOLONE, GLYCYLCYCLINE, GLYCOPEPTIDE, STREPTOGRAMIN, AND OXAZOLIDINONE TESTED ALONE AND IN COMBINATIONS AGAINST VANCOMYCIN-RESISTANT ENTEROCOCCUS-FAECIUM

We evaluated the in vitro activities of clinafloxacin, CL331,002, LY33 3328, quinupristin dalfopristin, and eperezolid (formerly known as U-1 00,592) against four strains of enterococci. All regimens tested resul ted in the growth inhibition of each isolate. Against the three clinaf loxacin-susceptible strains, clinafloxacin tested alone was the most a ctive treatment, decreasing the bacterial inoculum by more than 3 log( 10) CFU/ml after 24 h in time-kill curve studies.