G. Mejiabaltodano et al., HIGH RECURRENCE OF RECOMBINANTS IN A FAMILY WITH PERICENTRIC-INVERSION OF CHROMOSOME-18, Annales de genetique, 40(3), 1997, pp. 164-168
We report a family in which the father carries a pericentric inversion
involving two third of the chromosome 18 (p11.2q22), Of his three chi
ldren, the proposita and her youngest brother show partial duplication
of the short arm and partial deficiency of the long arm, the oldest s
ister shows the other recombinant (partial duplication of the long arm
and partial deficiency of the short arm). In the literature, we found
only one family in which both recombinants of a parental pericentric
inversion were present in the same offspring and none with three affec
teds and both kinds of recombinants. A review of the reported familial
cases reveals that the risk of aneusomy of recombination, at least fo
r chromosome-18 inversion carriers, may be close to 20 % and no only 5
-10 % as previously reported.