DETECTION OF DELTA-F508 MUTATION IN CYSTIC-FIBROSIS PATIENTS FROM NORTHWESTERN MEXICO

In order to know the frequency of Delta F508 allele in Northwestern Me xican patients with cystic fibrosis, we carried out the amplification of a region from exon 10 of the CF gene by means of PCR in 45 unrelate d patients selected by sweat test and clinical criteria, From 90 chrom osomes, only 31 (34.4 %) showed the Delta F508 mutation, distributed i n 9 homozygotes and 13 heterozygotes, These result suggest that other mutations are responsible of CF in the population of Northwestern Mexi co.