ANTIPROLIFERATION EFFECTS OF HEXADECYLPHOSPHOCHOLINE ON SOLID TUMOR AND LEUKEMIA SELECTIVELY IN-VITRO

Hexadecylphosphocholine (HePC), an alklylphospholipid analogue represe nting a new class oi antitumor agents, exerts sufficient oncolytic pot encies that it might be developed as a selective antitumour drug. This paper reports that 12 cell lines of leukaemia and solid tumour employ ed in this study were inhibited by HePC in vitro. This result indicate d that HePC possessed general antitumour properties, but did not inter fere significantly with cell proliferation of normal BMC: in tests of colony formation in granulocytic-macrophage colonies (CFU-GM). Because of these advantages, we suggest that HePC would be an excellent antit umour agent for selectively killing tumour cells and is of low toxicit y as compared to conventional cytotoxic agents.