PHASE-I CLINICAL-TRIAL OF CEFDITOREN PIVOXIL (ME1207) - TOLERANCE IN HEALTHY-VOLUNTEERS

A tolerance study to ME1207 was conducted in healthy volunteers using live single doses administered before a meal (50, 100, 200, 300 and 50 0mg), a single 200mg dose administered after a meal, and 200 mg admini stered every 12 h for 7 days. No subjective symptoms or changes in hae matological and biochemical examinations and urinalysis were observed after single administration of 50 to 500mg. Four subjects complained o i minimal upper abdominal discomfort when 200mg was administered every 12h for 7 days, but this symptom disappeared without remedial action in ail cases, Therefore, ME1207 was thought to be sale when orally adm inistered at the above-mentioned doses by the above-mentioned administ ration methods.