URINE VISCOSITY AFTER INJECTIONS OF IOTROLAN OR IOMEPROL

Purpose: Previous observations in rats caused us to speculate whether the injection of iotrolan, a nonionic dimeric contrast medium (CM), wo uld increase urine viscosity enough to obstruct urine outflow in the c ollecting duct. Material and Methods: The urine viscosity in dogs was measured directly with a viscosimeter after injections of iotrolan or of iomeprol, a nonionic monomeric CM. Results and Conclusion: The inje ction of iotrolan increased urine viscosity considerably whereas iomep rol had little effect on this variable. The osmolality-dependent adver se reactions of CM have previously been emphasized but viscosity-depen dent adverse reactions must also be considered when the CM is a polyme r with a low osmolality.