DEVELOPMENTAL-CHANGES IN UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE ACTIVITYOF RAT AND GUINEA-PIG LIVER

Authors
GAL B RUANO MJ PUENTE R GARCIAPARDO LA RUEDA R GIL A HUESO P
Citation
B. Gal et al., DEVELOPMENTAL-CHANGES IN UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE ACTIVITYOF RAT AND GUINEA-PIG LIVER, Comparative biochemistry and physiology. B. Comparative biochemistry, 118(1), 1997, pp. 13-15
Citations number
14
Categorie Soggetti
Biology
Journal title
Comparative biochemistry and physiology. B. Comparative biochemistry → ACNP
ISSN journal
03050491
Volume
118
Issue
1
Year of publication
1997
Pages
13 - 15
Database
ISI
SICI code
0305-0491(1997)118:1<13:DIU2A>2.0.ZU;2-7
Abstract
The activity of UDP-N-acetylglucosamine 2-epimerase was determined in the liver of rats and guinea-pigs of different ages. The activity of t his enzyme in rats was low at birth, increased to a maximum value on d ay 15, and fell gradually until day 30. Thereafter, it increased up to the 60th day. The activity profile of the enzyme from guinea-pig live r was very similar. However, guinea-pig activity was 2-5 times lower t han in rats. Both rats and guinea-pigs displayed similar liver sialic acid contents which increased from birth to 2 months of age. Rats also showed a N-glycolylneuraminic acid content that decreased from birth to 2 months. From these results we can inferred that postnatal UDP-N-a cetylglucosamine 2 epimerase activity seems to be correlated with age and the developmental states of rats and guinea-pigs. (C) 1997 Elsevie r Science Inc.