FREQUENCIES OF GB-VIRUS-C HEPATITIS-G VIRUS GENOMES AND OF SPECIFIC ANTIBODIES IN GERMAN RISK AND NON-RISK POPULATIONS

The prevalence of the new flavivirus GB virus C/hepatitis virus G (GBV -C/HGV) in different German populations was investigated by detection of viral genomes and anti-E2 antibodies. While blood donors had an ove rall prevalence of 10.4% there were increased rates for hemophiliacs ( 54.7%), hemodialysis patients (30.2%), male homosexuals (30.2%) and in travenous drug users (74.4%). Most GBV-C/HGV positive samples were eit her viral genome positive or antibody positive, exclusively. Samples w ith the rare constellation ''positive for both GBV-C/HGV genome and sp ecific antibody'' originated in almost all cases from patients who wer e additionally infected with HIV or HCV. Probable transmission of GBV- C/HGV by PCR-positive blood transfusions was observed in 5 of 6 cases approximately six months after transfusion. (C) 1997 Wiley-Liss, Inc.