CD3(-)CD4(-LIKE PATTERN OF CYTOKINE PRODUCTION IN THE PERIPHERAL-BLOOD OF A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA() CELLS WITH A TH2)

Authors
BRUGNONI D AIRO P TOSONI C TAGLIETTI M LODIRIZZINI F CALZAVARAPINTON P LEALI C CATTANEO R
Citation
D. Brugnoni et al., CD3(-)CD4(-LIKE PATTERN OF CYTOKINE PRODUCTION IN THE PERIPHERAL-BLOOD OF A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA() CELLS WITH A TH2), Leukemia, 11(11), 1997, pp. 1983-1985
Citations number
8
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
11
Issue
11
Year of publication
1997
Pages
1983 - 1985
Database
ISI
SICI code
0887-6924(1997)11:11<1983:CPOCPI>2.0.ZU;2-C
Abstract
A case of cutaneous T cell lymphoma associated with mild eosinophilia and rise of IgE levels is reported. A population of CD3(-)CD4(+) cells was observed in the peripheral blood. After activation, these purifie d CD3(-)CD4(+) cells showed a Th2 pattern of cytokine production, secr eting higher levels of IL-5 and IL-4 and lower levels of IFN-gamma com pared to the patient's and controls' CD3(+)CD4(+) cells. Moreover, hig h levels of IL-5 and soluble CD30, a marker of Th2 cell activation, we re detected in the patient's serum.