IN-SITU CHEMICAL TAGGING - TETRAFLUOROPHTHALIC ANHYDRIDE AS A SEQUESTRATION ENABLING REAGENT (SER) IN THE PURIFICATION OF SOLUTION-PHASE COMBINATORIAL LIBRARIES

Authors
PARLOW JJ NAING W SOUTH MS FLYNN DL
Citation
Jj. Parlow et al., IN-SITU CHEMICAL TAGGING - TETRAFLUOROPHTHALIC ANHYDRIDE AS A SEQUESTRATION ENABLING REAGENT (SER) IN THE PURIFICATION OF SOLUTION-PHASE COMBINATORIAL LIBRARIES, Tetrahedron letters, 38(46), 1997, pp. 7959-7962
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
46
Year of publication
1997
Pages
7959 - 7962
Database
ISI
SICI code
0040-4039(1997)38:46<7959:ICT-TA>2.0.ZU;2-Z
Abstract
A specific example of a Sequestration Enabling Reagent (SER), tetraflu orophthalic anhydride, is used in the purification of solution-phase r eactions involving amines with electrophiles. The SER is added to an i ncomplete reaction mixture containing product, amine, and electrophile . The SER covalently reacts with remaining amine, affording a derivati zed amine with an artificially-imparted acid rag. This ''tagged'' amin e is now sequesterable by the same CMR/R polyamine resin used to seque ster the electrophile and both are easily removed from the reaction mi xture affording pure product. (C) 1997 Elsevier Science Ltd.